Allogeneic iNKT Cell Therapy (agenT-797) After SCT ALLOGENEIC INKT CELL THERAPY (AGENT-797) AFTER SCT

What's the purpose of this trial?

The goal of this clinical trial is to learn if agenT-797 is safe to use on people undergoing allogenic hematological stem cell transplantation (SCT). The main questions it aims to answer are: * Is agenT-797 safe to use? * What medical problems do participants have when taking agenT-797? Participants will receive an infusion of agenT-797 about 7 days after their allogenic SCT.

This is an upcoming trial that has not yet started accepting patients.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

* Age ≥18 years at the time of consent
* Adult patients anticipated to get an allogeneic hematopoietic cell transplantation (allo-SCT)
* All donor types are accepted (MMUD \[mismatched unrelated donor\], MUD \[matched unrelated donor\], MSD \[matched sibling donor\], haploidentical)
* All conditioning regimens will be accepted (MAC \[myeloablative conditioning\], RIC \[reduced-intensity conditioning\], NMAC \[non-myeloablative conditioning\])
* Karnofsky Performance Scale (KPS) \> 70
* Eligible Diagnoses:

* Acute myeloid leukemia (AML) with intermediate/high-risk features or relapsed disease
* Chronic myeloid leukemia (CML) in accelerated or blast phases
* Myelodysplastic syndrome (MDS) with intermediate/high-risk features
* Acute lymphoblastic leukemia (ALL) with high-risk features or relapsed disease
* or any patients undergoing allogeneic stem cell transplant (allo-SCT) as standard of care could be eligible

Exclusion Criteria:

* Excluded Diagnoses: Primary Myelofibrosis in the dose escalation phase and could be included in the dose-expansion phase

Additional Trial Information

Phase 1

Enrollment: 22 patients (estimated)

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Trial Locations

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Wisconsin

University of Wisconsin - Carbone Cancer Center University of Wisconsin Health

Madison, WI

Not Yet Accepting
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