MOMENTUM: A Phase 2 Clinical Trial Evaluating the Safety and Efficacy of Cemsidomide in Combination with Dexamethasone in Patients with Relapsed or Refractory Multiple Myeloma MOMENTUM

What's the purpose of this trial?

The goal of this clinical trial is to learn more about the safety and efficacy of cemsidomide when given in combination with dexamethasone in patients who have relapsed or refractory multiple myeloma.

This trial is currently open and accepting patients.

What will happen during the trial?

In this research study, all patients will receive cemsidomide and dexamethasone in cycles. Each cycle in this study will be 28 days (4 weeks). 

Patients will take 100 micrograms of cemsidomide by mouth once a day for 14 days, then no cemsidomide for the next 14 days. Patients will also take dexamethasone by mouth once a week. The dose of dexamethasone received depends on the age of the participant.

Patients may continue receiving cemsidomide and dexamethasone until their myeloma gets worse, they have side effects they cannot tolerate, they choose to withdraw from the study, or the study is stopped.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

  • have measurable disease as defined by the trial criteria.
  • have received at least three prior lines of therapy that must have included an immunomodulatory drug, proteasome inhibitor, anti-CD38 antibody, and a T-cell engager or CAR-T cell therapy unless not indicated and/or patient refusal.
  • were refractory to, or had disease progression within 60 days from last dose of most recent line of therapy.
  • have not received mezigdomide or iberdomide during your most recent line of therapy.
  • have not previously received cemsidomide.
  • do not have myeloma involvement in your central nervous system.

Additional Trial Information

Phase 2

Enrollment: 100 patients (estimated)

View More
Need Help?

Interested in joining or learning more about this trial?

(888) 828-2206

Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

Alabama

Clearview Cancer Institute

Huntsville, AL

Open and Accepting

Arizona

Mayo Clinic (Arizona)

Phoenix, AZ

Open and Accepting

HonorHealth Research and Innovation Institute

Scottsdale, AZ

Open and Accepting

California

City of Hope Comprehensive Cancer Center Beckman Research Institute

Duarte, CA

Open and Accepting

James R Berenson, MD, Inc.

West Hollywood, CA

Open and Accepting

Florida

Mayo Clinic (Jacksonville)

Jacksonville, FL

Open and Accepting

Georgia

Winship Cancer Institute Emory University

Atlanta, GA

Open and Accepting

Indiana

Simon Cancer Center Indiana University

Indianapolis, IN

Open and Accepting

Iowa

Holden Comprehensive Cancer Center - University of Iowa University of Iowa Hospitals and Clinics

Iowa City, IA

Open and Accepting

Massachusetts

Massachusetts General Hospital

Boston, MA

Open and Accepting

Dana-Farber Cancer Institute

Boston, MA

Open and Accepting

Michigan

University of Michigan Comprehensive Cancer Center Rogel Cancer Center

Ann Arbor, MI

Open and Accepting

Barbara Ann Karmanos Cancer Institute Wayne State University

Detroit, MI

Open and Accepting

START Midwest Midwest

Grand Rapids, MI

Open and Accepting

Minnesota

Mayo Clinic (Rochester)

Rochester, MN

Open and Accepting

Missouri

Alvin J. Siteman Cancer Center Washington University Medical Campus

St. Louis, MO

Open and Accepting

Nebraska

University of Nebraska Medical Center Fred & Pamela Buffett Cancer Center

Omaha, NE

Open and Accepting

New York

Memorial Sloan Kettering Cancer Center

New York, NY

Open and Accepting

Mount Sinai Hospital Tisch Cancer Institute

New York, NY

Open and Accepting

North Carolina

UNC Lineberger Comprehensive Cancer Center University of North Carolina

Chapel Hill, NC

Open and Accepting

Tennessee

Tennessee Oncology - Hayes

Nashville, TN

Open and Accepting

Texas

The START Center - San Antonio South Texas Accelerated Research Therapeutics

San Antonio, TX

Open and Accepting

Wisconsin

University of Wisconsin - Carbone Cancer Center University of Wisconsin Health

Madison, WI

Open and Accepting

Medical College of Wisconsin Froedtert Hospital

Milwaukee, WI

Open and Accepting
Interested in this trial?
  • Call us today 😀 keyboard_arrow_right

    We know how difficult and confusing this process can be. If you are interested in this clinical trial or have questions, you can call us at any time. You can also send us a direct message with questions.

    (888) 828-2206
  • Add this trial to your favorites keyboard_arrow_right

    If you are interested in keeping an eye on this trial, you can add it to your list of favorite trials. We'll send you alerts when this trial is updated.

  • Talk to your doctor keyboard_arrow_right

    You can print an overview of this trial to take in to your next appointment. Your doctor can help you understand if this trial may be right for you.

Still need help? Send us a message