A Measurable Residual Disease (MRD) Driven, Phase II Study of Venetoclax Plus Chemotherapy for Newly Diagnosed Younger Patients With Intermediate Risk Acute Myeloid Leukemia: A Tier 1 MYELOMATCH Clinical Trial MYELOMATCH: VENETOCLAX + CHEMOTHERAPY

What's the purpose of this trial?

For people with newly diagnosed acute myeloid leukemia (AML), the more leukemia cells are destroyed, the better their long-term outcomes. In this study, researchers want to see adding venetoclax to standard chemotherapy (daunorubicin/cytarabine) or giving it with azacitidine works better than standard therapy for getting rid of the small amount of remaining leukemia cells. The people in this study include young adults with intermediate-risk AML.

Venetoclax is in a class of medications called BCL-2 inhibitors. It may stop the growth of cancer cells by blocking BCL-2, a protein cancer cells need to survive.

If you join this study, you will get one of these regimens of treatment:

  • Daunorubicin, cytarabine, and venetoclax
  • Azacitidine and venetoclax
  • Daunorubicin and cytarabine

This trial is currently open and accepting patients.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

To join this study, there are a few conditions. You must:

  • Be age 18-59.
  • Have newly diagnosed AML with features indicating an intermediate risk of it coming back after treatment.
  • You may join this study even if you have leukemia in the brain and spinal space.

Additional Trial Information

Phase 2

Enrollment: 153 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

Alabama

University of Alabama at Birmingham O'Neal Comprehensive Cancer Center

Birmingham, AL

Open and Accepting

Arizona

Banner Health University Medical Center

Tucson, AZ

Open and Accepting

University of Arizona Cancer Center

Tucson, AZ

Open and Accepting

California

Alta Bates Cancer Care Center

Berkeley, CA

Open and Accepting

Cedars-Sinai Medical Center - UCLA School of Medicine Samuel Oschin Comprehensive Cancer Institute

Los Angeles, CA

Open and Accepting

Idaho

Saint Alphonsus Cancer Care Center (Boise)

Boise City, ID

Open and Accepting

Saint Alphonsus Cancer Care Center (Caldwell)

Caldwell, ID

Open and Accepting

Kootenai Clinic Cancer Services - Coeur d'Alene

Coeur d'Alene, ID

Open and Accepting

Saint Luke's Mountain States Tumor Institute (Fruitland)

Fruitland, ID

Open and Accepting

St. Luke's Cancer Institute (Meridian)

Meridian, ID

Open and Accepting

Saint Alphonsus Cancer Care Center (Nampa)

Nampa, ID

Open and Accepting

Saint Luke's Mountain States Tumor Institute (Nampa)

Nampa, ID

Open and Accepting

Kootenai Cancer Center

Post Falls, ID

Open and Accepting

Kootenai Clinic

Sandpoint, ID

Open and Accepting

Illinois

Centralia Oncology Clinic

Centralia, IL

Open and Accepting

University of Chicago Medicine Comprehensive Cancer Center

Chicago, IL

Open and Accepting

Robert H. Lurie Comprehensive Cancer Center Northwestern University Feinberg School of Medicine

Chicago, IL

Open and Accepting

Cancer Care Specialists of IL - Cancer Care Center of Decatur

Decatur, IL

Open and Accepting

Memorial Health - Decatur Memorial Hospital Memorial Health

Decatur, IL

Open and Accepting

Cancer Care Specialists (Crossroads Cancer Center)

Effingham, IL

Open and Accepting

NorthShore University Health System - Evanston Hospital

Evanston, IL

Open and Accepting

NorthShore University Health System Glenbrook Hospital

Glenview, IL

Open and Accepting

NorthShore University Health System (Highland Park Hospital)

Highland Park, IL

Open and Accepting

Loyola University Medical Center Cardinal Bernardin Cancer Center

Maywood, IL

Open and Accepting

University of Chicago Cancer Center at Silver Cross

New Lenox, IL

Open and Accepting

Cancer Care Center of O'Fallon

O'Fallon, IL

Open and Accepting

University of Chicago Medicine Orland Park

Orland Park, IL

Open and Accepting

Southern Illinois University School of Medicine - Simmons Cancer Institute

Springfield, IL

Open and Accepting

Springfield Clinic 1st - 900 Building

Springfield, IL

Open and Accepting

Memorial Medical Center

Springfield, IL

Open and Accepting

Springfield Clinic Main Campus East

Springfield, IL

Open and Accepting

Iowa

Holden Comprehensive Cancer Center - University of Iowa University of Iowa Hospitals and Clinics

Iowa City, IA

Open and Accepting

Kansas

University of Kansas Cancer Center

Kansas City, KS

Open and Accepting

University of Kansas Cancer Center (Indian Creek)

Overland Park, KS

Open and Accepting

University of Kansas Cancer Center (Westwood)

Westwood, KS

Open and Accepting

Kentucky

UK Markey Cancer Center University of Kentucky

Lexington, KY

Open and Accepting

Louisiana

LSU Health Baton Rouge (North Clinic)

Baton Rouge, LA

Open and Accepting

Our Lady of the Lake Regional Medical Center

Baton Rouge, LA

Open and Accepting

Maine

Maine Medical Center - Bramhall Campus MaineHealth

Portland, ME

Open and Accepting

MaineHealth Cancer Care - South Portland

South Portland, ME

Open and Accepting

Massachusetts

Tufts Medical Center Cancer Center

Boston, MA

Open and Accepting

Beth Israel Lahey Hospital and Medical Center

Burlington, MA

Open and Accepting

Lahey Medical Center

Peabody, MA

Open and Accepting

Michigan

IHA Hematology Oncology at St. Joe's Brighton

Brighton, MI

Open and Accepting

Michigan Cancer Research Consortium - Trinity Health Medical Center – Canton

Canton, MI

Open and Accepting

IHA Hematology Oncology at St. Joe's Chelsea

Chelsea, MI

Open and Accepting

Henry Ford Hospital

Detroit, MI

Open and Accepting

The Cancer & Hematology Centers

Flint, MI

Open and Accepting

Genesys Hurley Cancer Institute

Flint, MI

Open and Accepting

Hurley Medical Center

Flint, MI

Open and Accepting

St. Mary Mercy Hospital St. Joe's Health

Livonia, MI

Open and Accepting

Henry Ford Medical Center (Columbus)

Novi, MI

Open and Accepting

Henry Ford Medical Center (West Bloomfield)

West Bloomfield, MI

Open and Accepting

Minnesota

Mercy Hospital

Coon Rapids, MN

Open and Accepting

Essentia Health

Deer River, MN

Open and Accepting

Essentia Health (Duluth Clinic)

Duluth, MN

Open and Accepting

Fairview Southdale Hospital

Edina, MN

Open and Accepting

Essentia Health Hibbing Clinic

Hibbing, MN

Open and Accepting

Abbott-Northwestern Hospital Allina Health Cancer Institute

Minneapolis, MN

Open and Accepting

Essentia Health (Sandstone)

Sandstone, MN

Open and Accepting

Park Nicollet Clinic

St. Louis Park, MN

Open and Accepting

Regions Hospital

St. Paul, MN

Open and Accepting

United Hospital

St. Paul, MN

Open and Accepting

Essentia Health Virginia Clinic

Virginia, MN

Open and Accepting

Mississippi

Baptist Memorial Hospital and Cancer Center-Golden Triangle

Columbus, MS

Open and Accepting

Baptist Cancer Center-Grenada

Grenada, MS

Open and Accepting

Baptist Memorial Hospital and Cancer Center-Union County

New Albany, MS

Open and Accepting

Baptist Memorial Hospital and Cancer Center-Oxford

Oxford, MS

Open and Accepting

Baptist Memorial Hospital and Cancer Center-Desoto

Southhaven, MS

Open and Accepting

Missouri

Siteman Cancer Center at Barnes-Jewish West County Hospital

Creve Coeur, MO

Open and Accepting

Siteman Cancer Center at Christian Hospital

Saint Louis, MO

Open and Accepting

Siteman Cancer Center at Saint Peters Hospital

Saint Peters, MO

Open and Accepting

Siteman Cancer Center (South St. Louis County)

St. Louis, MO

Open and Accepting

Montana

Community Hospital of Anaconda

Anaconda, MT

Open and Accepting

Billings Clinic Cancer Center

Billings, MT

Open and Accepting

Bozeman Deaconess Hospital

Bozeman, MT

Open and Accepting

Benefis Sletten Cancer Institute

Great Falls, MT

Open and Accepting

Kalispell Regional Medical Center

Kalispell, MT

Open and Accepting

Community Medical Hospital

Missoula, MT

Open and Accepting

Nebraska

Nebraska Medicine (Bellevue Medical Center)

Bellevue, NE

Open and Accepting

Nebraska Medicine (Village Pointe)

Omaha, NE

Open and Accepting

University of Nebraska Medical Center Fred & Pamela Buffett Cancer Center

Omaha, NE

Open and Accepting

Nevada

OptumCare Cancer Care at Seven Hills

Henderson, NV

Open and Accepting

Optum Care Cancer Center - Charleston

Las Vegas, NV

Open and Accepting

OptumCare Cancer Care at Fort Apache

Las Vegas, NV

Open and Accepting

New Hampshire

Dartmouth-Hitchcock Medical Center Norris Cotton Cancer Center

Lebanon, NH

Open and Accepting

New Jersey

Memorial Sloan Kettering Basking Ridge

Basking Ridge, NJ

Open and Accepting

Cooperman Barnabas Medical Center

Livingston, NJ

Open and Accepting

Monmouth Medical Center Rutgers University

Long Branch, NJ

Open and Accepting

Memorial Sloan Kettering Monmouth

Middletown, NJ

Open and Accepting

Memorial Sloan Kettering Bergen

Montvale, NJ

Open and Accepting

Rutgers Cancer Institute of New Jersey Rutgers, The State University of New Jersey

New Brunswick, NJ

Open and Accepting

Valley Health System - Luckow Pavilion

Paramus, NJ

Open and Accepting

The Valley Hospital

Ridgewood, NJ

Open and Accepting

New Mexico

University of New Mexico Comprehensive Cancer Center

Albuquerque, NM

Open and Accepting

New York

Memorial Sloan Kettering Cancer Center

New York, NY

Open and Accepting

Roswell Park Cancer Institute

Buffalo, NY

Open and Accepting

Memorial Sloan Kettering Commack

Commack, NY

Open and Accepting

University of Rochester Medical Center Wilmot Cancer Center Strong Memorial Hospital

Rochester, NY

Open and Accepting

Montefiore Medical Center (Moses Campus)

The Bronx, NY

Open and Accepting

Memorial Sloan Kettering Nassau

Uniondale, NY

Open and Accepting

Memorial Sloan Kettering Westchester

West Harrison, NY

Open and Accepting

North Carolina

Wake Forest Baptist - Comprehensive Cancer Center Atrium Health

Winston-Salem, NC

Open and Accepting

Novant Health Presbyterian Medical Center Novant Health

Charlotte, NC

Open and Accepting

Duke Cancer Center Duke University Medical Center

Durham, NC

Open and Accepting

Novant Health Forsyth Medical Center - Silas Creek

Winston-Salem, NC

Open and Accepting

Ohio

Case Western Reserve University

Cleveland, OH

Open and Accepting

Oklahoma

University of Oklahoma Health Sciences Center

Oklahoma City, OK

Open and Accepting

Oregon

Saint Alphonsus Medical Center (Ontario)

Ontario, OR

Open and Accepting

Providence Oncology and Hematology - Eastside Providence Cancer Institute Franz Clinic

Portland, OR

Open and Accepting

Providence Oncology and Hematology - Westside Providence St. Vincent Medical Center

Portland, OR

Open and Accepting

Pennsylvania

Lehigh Valley Hospital-Cedar Crest

Allentown, PA

Open and Accepting

Geisinger Medical Center - Danville

Danville, PA

Open and Accepting

Penn State Hershey Medical Center

Hershey, PA

Open and Accepting

Geisinger Health System (Lewistown Hospital)

Lewistown, PA

Open and Accepting

Tower Health Reading Hospital

West Reading, PA

Open and Accepting

South Carolina

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, SC

Open and Accepting

Prisma Health Cancer Institute - Easley Easley

Easley, SC

Open and Accepting

Greenville Health System Cancer Institute (Butternut)

Greenville, SC

Open and Accepting

Prisma Health Cancer Institute - Faris

Greenville, SC

Open and Accepting

Prisma Health Cancer Institute - Eastside Eastside

Greenville, SC

Open and Accepting

Prisma Health Cancer Institute - Greer Greer

Greer, SC

Open and Accepting

Prisma Health Cancer Institute - Seneca Lila Doyle Drive

Seneca, SC

Open and Accepting

Tennessee

Baptist Memorial Hospital and Cancer Center-Collierville

Collierville, TN

Open and Accepting

Baptist Clinical Research Institute

Memphis, TN

Open and Accepting

Texas

Baylor College of Medicine - Dan L. Duncan Comprehensive Cancer Center

Houston, TX

Open and Accepting

Ben Taub Hospital

Houston, TX

Open and Accepting

Utah

Huntsman Cancer Institute University of Utah

Salt Lake City, UT

Open and Accepting

Virginia

UVA Cancer Center University of Virginia Health System

Charlottesville, VA

Open and Accepting

Inova Schar Cancer Institute Inova Fairfax Hospital

Fairfax, VA

Open and Accepting

Inova Fairfax Medical Hospital Inova Schar Cancer Institute

Falls Church, VA

Open and Accepting

Washington

Swedish Cancer Institute Swedish Edmonds Campus

Edmonds, WA

Open and Accepting

Swedish Cancer Institute

Issaquah, WA

Open and Accepting

Swedish - First Hill Campus

Seattle, WA

Open and Accepting

Wisconsin

Medical College of Wisconsin Froedtert Hospital

Milwaukee, WI

Open and Accepting

Essentia Health - Ashland Clinic

Ashland, WI

Open and Accepting

Green Bay Oncology (HSHS St. Vincent Hospital) Saint Vincent Hospital

Green Bay, WI

Open and Accepting

Gundersen Lutheran Medical Center

La Crosse, WI

Open and Accepting
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