A Phase 1b/2, Open-Label, Master Protocol Study of BTK-Degrader BGB-16673 in Combination With Other Agents in Patients With Relapsed or Refractory B-Cell Malignancies BGB-16673 COMBINATION THERAPY

What's the purpose of this trial?

Researchers are assessing treatment with BGB-16673 in combination with other anti-cancer medications in people with B-cell cancers. These cancers include:

  • Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma
  • Follicular lymphoma
  • Richter’s transformation
  • Waldenstrom macroglobulinemia
  • Marginal zone lymphoma
  • Mantle cell lymphoma

The people in this study have cancer that came back or keeps growing after treatment.

BGB-16673 degrades a protein called BTK. BTK plays a role in the survival of CLL cells. If you join this study, you will get BGB-16673 plus one of these drugs, depending on the study group that you participate in:

  • Sonrotoclax. This drug inhibits a protein called Bcl-2. Bcl-2 stops cancer cells from dying.
  • Zanubrutinib. This drug is a BTK inhibitor.
  • Mosunetuzumab. This bispecific antibody helps the immune system fight cancer by directing T cells to kill cancerous B cells.

BGB-16673, sonrotoclax, and zanubrutinib are each taken orally (by mouth). Mosunetuzumab is given as a subcutaneous (under the skin) injection.

This trial is currently open and accepting patients.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

To join this study, there are a few conditions. You must:

  • Have a B-cell cancer that came back or keeps growing after treatment.
  • Have recovered from the serious side effects of previous therapies before getting the study treatment.
  • Be able to walk and do routine activities for more than half the time you are awake.
  • Be age 18 or older.

Additional Trial Information

Phase 1/2

Enrollment: 80 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

Arizona

Mayo Clinic (Arizona)

Phoenix, AZ

Open and Accepting

California

USC Norris Comprehensive Cancer Center - Keck School of Medicine University of Southern California

Los Angeles, CA

Open and Accepting

Florida

Mayo Clinic (Jacksonville)

Jacksonville, FL

Open and Accepting

Moffitt Cancer Center Magnolia Campus

Tampa, FL

Open and Accepting

Kansas

University of Kansas Cancer Center (Westwood)

Westwood, KS

Open and Accepting

Minnesota

Mayo Clinic (Rochester)

Rochester, MN

Open and Accepting

New Jersey

Memorial Sloan Kettering Basking Ridge

Basking Ridge, NJ

Open and Accepting

Memorial Sloan Kettering Monmouth

Middletown, NJ

Open and Accepting

Memorial Sloan Kettering Bergen

Montvale, NJ

Open and Accepting

New York

Memorial Sloan Kettering Cancer Center

New York, NY

Open and Accepting

Memorial Sloan Kettering Commack

Commack, NY

Open and Accepting

Weill Cornell

New York, NY

Open and Accepting

Mount Sinai Hospital Tisch Cancer Institute

New York, NY

Open and Accepting

University of Rochester Medical Center Wilmot Cancer Center Strong Memorial Hospital

Rochester, NY

Open and Accepting

Memorial Sloan Kettering Nassau

Uniondale, NY

Open and Accepting

Memorial Sloan Kettering Westchester

West Harrison, NY

Open and Accepting

Pennsylvania

Fox Chase Cancer Center Temple Health

Philadelphia, PA

Open and Accepting

Texas

MD Anderson Cancer Center The University of Texas

Houston, TX

Open and Accepting

Utah

Huntsman Cancer Institute University of Utah

Salt Lake City, UT

Open and Accepting

Wisconsin

University of Wisconsin - Carbone Cancer Center University of Wisconsin Health

Madison, WI

Open and Accepting
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