A Phase 2 Study of Azacitidine and Venetoclax to Treat Acute Myeloid Leukemia Patients With Measurable Residual Disease Before an Allogeneic Stem Cell Transplant AZACITIDINE AND VENETOCLAX FOR MRD
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What's the purpose of this trial?

Some people treated for acute myeloid leukemia (AML) with induction (initial) chemotherapy are left with minimal residual disease (MRD). With MRD, there is a small number of leukemia cells from the bone marrow remaining in the body. MRD increases the chance that the cancer will come back after a bone marrow transplant from a donor.

The drugs azacitidine and venetoclax may work well to get rid of or lower MRD in people with AML. Researchers are doing this study to see if this can be achieved with one treatment cycle of azacitidine and venetoclax. They hope that giving these drugs before a bone marrow transplant will reduce the chance of the leukemia coming back. Azacitidine is given intravenously (by vein) or as an injection, and venetoclax is taken orally (by mouth).

This trial is currently open and accepting patients.


You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

To join this study, there are a few conditions. You must:

  • Have AML with MRD after induction chemotherapy.
  • Be planning to receive a bone marrow transplant from a donor.
  • Be age 18 or older.
  • You may join this study even if you need help taking care of yourself. You may also join even if you are in a bed or chair for more than half the time you’re awake.

Additional Trial Information

Phase 2

Enrollment: 30 patients (estimated)

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Trial Locations

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New Jersey

Memorial Sloan Kettering Basking Ridge

Basking Ridge, NJ

Open and Accepting

Memorial Sloan Kettering Monmouth

Middletown, NJ

Open and Accepting

Memorial Sloan Kettering Bergen

Montvale, NJ

Open and Accepting

New York

Memorial Sloan Kettering Cancer Center

New York, NY

Open and Accepting

Memorial Sloan Kettering Commack

Commack, NY

Open and Accepting

Memorial Sloan Kettering Nassau

Uniondale, NY

Open and Accepting

Memorial Sloan Kettering Westchester

West Harrison, NY

Open and Accepting
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