Some people treated for acute myeloid leukemia (AML) with induction (initial) chemotherapy are left with minimal residual disease (MRD). With MRD, there is a small number of leukemia cells from the bone marrow remaining in the body. MRD increases the chance that the cancer will come back after a bone marrow transplant from a donor.
The drugs azacitidine and venetoclax may work well to get rid of or lower MRD in people with AML. Researchers are doing this study to see if this can be achieved with one treatment cycle of azacitidine and venetoclax. They hope that giving these drugs before a bone marrow transplant will reduce the chance of the leukemia coming back. Azacitidine is given intravenously (by vein) or as an injection, and venetoclax is taken orally (by mouth).
This trial is currently open and accepting patients.
The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.
To join this study, there are a few conditions. You must:
Phase 2
Enrollment: 30 patients (estimated)
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