A First-in-Human Study of ABBV-525 (MALT1 Inhibitor) in B-Cell Malignancies ABBV-525
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What's the purpose of this trial?

In this study, researchers want to find the highest dose of the drug ABBV-525 to safely treat B-cell non-Hodgkin lymphoma (NHL). People in this study have B-cell NHL that keeps growing even after standard treatment.

ABBV-525 works by blocking a protein called MALT1. This protein can help B-cell cancers live and grow. Blocking MALT1 may kill cancer cells or stop them from growing. ABBV-525 is taken orally (by mouth).

This trial is currently open and accepting patients.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

To join this study, there are a few conditions. You must:

  • Have B-cell NHL that keeps growing even after treatment.
  • Have finished all other therapies at least 4 weeks before you get ABBV-525.
  • Be well enough to walk and take care of yourself. You must be able to do activities such as office work or light housework.
  • Be age 18 and older.

Additional Trial Information

Phase 1

Enrollment: 150 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

California

UCLA Medical Center of Hematology/Oncology

Los Angeles, CA

Open and Accepting

Connecticut

Smilow Cancer Hospital at Yale New Haven

New Haven, CT

Open and Accepting

Indiana

Simon Cancer Center Indiana University

Indianapolis, IN

Open and Accepting

Louisiana

Tulane Cancer Center Tulane University School of Medicine

New Orleans, LA

Open and Accepting

Michigan

START Midwest Midwest

Grand Rapids, MI

Open and Accepting

New Jersey

Memorial Sloan Kettering Basking Ridge

Basking Ridge, NJ

Open and Accepting

Memorial Sloan Kettering Monmouth

Middletown, NJ

Open and Accepting

Memorial Sloan Kettering Bergen

Montvale, NJ

Open and Accepting

New York

Memorial Sloan Kettering Cancer Center

New York, NY

Open and Accepting

Memorial Sloan Kettering Commack

Commack, NY

Open and Accepting

Memorial Sloan Kettering Nassau

Uniondale, NY

Open and Accepting

Memorial Sloan Kettering Westchester

West Harrison, NY

Open and Accepting

North Carolina

Atrium Health's Levine Cancer Institute - Charlotte (Main) Atrium Health

Charlotte, NC

Open and Accepting

Ohio

Barrett Cancer Center University of Cincinnati Health

Cincinnati, OH

Open and Accepting

Texas

MD Anderson Cancer Center The University of Texas

Houston, TX

Open and Accepting

Utah

Huntsman Cancer Institute University of Utah

Salt Lake City, UT

Open and Accepting

Washington

Northwest Medical Specialties (Tacoma) NWMS Tacoma — Medical Oncology & Infectious Diseases

Tacoma, WA

Open and Accepting
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