New Jersey
New York
In this study, researchers want to find the best doses of 2 different drug combinations. This study is for people with acute myeloid leukemia (AML) that keeps growing even after treatment. You also must have changes (mutations or variants) in the FLT3 gene, and in either the IDH1 or IDH2 genes. The FLT3 gene can cause cancer cells to grow. The IDH1 and IDH2 genes cause low blood cell counts.
If you join this study, you will get gilteritinib and either ivosidenib or enasidenib. Gilteritinib targets cells that make the FLT3 protein, which may cause cancer cells to die. Ivosidenib blocks the mutated IDH1 protein. Enasidenib blocks the mutated IDH2 protein, which raises blood cell counts. All 3 medications are taken orally (by mouth).
This trial is currently open and accepting patients.
The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.
To join this study, there are a few conditions. You must:
Phase 1
Enrollment: 36 patients (estimated)
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