Phase 3 Clinical Trial Comparing the Safety and Effectiveness of Elranatamab Versus Commonly Used Combination Regimens in Participants with Relapsed/Refractory Multiple Myeloma MAGNETISMM-32
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What's the purpose of this trial?

The goal of this clinical trial is to compare the safety and effectiveness of Elranatamab versus commonly used combination regimens in participants with relapsed/refractory multiple myeloma.

This trial is currently open and accepting patients.

What will happen during the trial?

Participants will be randomly assigned into either the experimental group (receiving elranatamab) or the comparator group (receiving one of three commonly used combination treatment regimens that will be selected by the study doctor). This study is open-label, which means that both researchers and participants will know which groups the participants have been placed in, and which treatments they will be receiving. Participants may continue to receive treatment as long as they don’t experience unacceptable side effects and their myeloma doesn’t get worse.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

  • have multiple myeloma that has worsened or not responded to last line of therapy.
  • have received between 1-4 prior lines of therapy which includes:
    • at least 2 consecutive cycles of an anti-CD38 antibody, and
    • at least 2 consecutive cycles of lenalidomide.
  • have not previously received treatment with a BCMA or CD3 targeted therapy.
  • are eligible to receive at least one of the comparator regimens of the study.
  • have adequate cardiac, liver and kidney function.

Additional eligibility criteria apply and can be explained by the study doctor. 

Additional Trial Information

Phase 3

Enrollment: 492 patients (estimated)

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Interested in joining or learning more about this trial?

(888) 828-2206

Trial Links

Read the latest news and updates on this trial.

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Trial Locations

All Trial Locations

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Alabama

Infirmary Cancer Care

Mobile, AL

Open and Accepting

Arizona

City of Hope

Goodyear, AZ

Open and Accepting

California

Beverly Hills Cancer Center

Beverly Hills, CA

Open and Accepting

Valkyrie Clinical Trials

Los Angeles, CA

Open and Accepting

Hoag Memorial Hospital Presbyterian

Newport Beach, CA

Open and Accepting

University of California Davis Comprehensive Cancer Center

Sacramento, CA

Open and Accepting

Colorado

University of Colorado Health - Harmony

Fort Collins, CO

Open and Accepting

Florida

Boca Raton Clinical Research (BRCR) Medical Center

Plantation, FL

Open and Accepting

Boca Raton Clinical Research (BRCR) Medical Center

Tamarac, FL

Open and Accepting

Illinois

City of Hope

Zion, IL

Open and Accepting

Indiana

Community Health Network - South

Indianapolis, IN

Open and Accepting

Nebraska

Nebraska Hematology Oncology

Lincoln, NE

Open and Accepting

New Jersey

Morristown Medical Center Atlantic Health System

Morristown, NJ

Open and Accepting

New York

Cayuga Medical Center

Ithaca, NY

Open and Accepting

North Carolina

East Carolina University Vidant Cancer Care Eddie and Jo Allison Smith Tower

Greenville, NC

Open and Accepting

Ohio

TriHealth Cancer Institute (Good Samaritan Hospital)

Cincinnati, OH

Open and Accepting

Pennsylvania

West Penn Hospital (Allegheny Health Network)

Pittsburgh, PA

Open and Accepting

Rhode Island

Lifespan Cancer Institute The Miriam Hospital

Providence, RI

Open and Accepting

South Carolina

Saint Francis Hospital Cancer Center

Greenville, SC

Open and Accepting

Texas

Houston Methodist Hospital

Houston, TX

Open and Accepting

West Virginia

WVU Cancer Institute Mary Babb Randolph Cancer Center

Morgantown, WV

Open and Accepting
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