Multiple Myeloma Support + Trials

What's the purpose of this trial?

The purpose of this study is to assess BMS-986453 in participants with relapsed and/or refractory multiple myeloma (RRMM).

This trial is currently open and accepting patients.

What will happen during the trial?

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

Inclusion Criteria:

* Participants must have a diagnosis of multiple myeloma with relapsed and/or refractory disease.
* Participants must have confirmed progressive disease on or within 12 months (measured from the last dose) of completing treatment with the last anti-myeloma treatment regimen before study entry.
* Participants in Part A and Part B Cohort 1 and in Part B Cohort 2 must have received prevous anti-myeloma therapy, including a proteasome inhibitor and an immunomodulatory agent.
* Participants must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* Participants must have adequate organ function.

Exclusion Criteria:

* Participants must not have any known active or history of central nervous system (CNS) involvement of multiple myeloma.
* Participants must not have active or history of plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes) syndrome, or clinically significant amyloidosis.
* Participants must not have a history or presence of clinically significant CNS pathology such as seizure disorder, aphasia, stroke, severe brain injury, dementia, Parkinson's disease, or cerebellar disease, or presence of clinically active psychosis.

Other protocol-defined inclusion/exclusion criteria apply

Additional Trial Information

Phase 1

Enrollment: 150 patients (estimated)

Need Help?

Interested in joining or learning more about this trial?

(888) 828-2206

Interested in this trial?

Call us today 😀

We know how difficult and confusing this process can be. If you are interested in this clinical trial or have questions, you can call us at any time. You can also send us a direct message with questions.
(888) 828-2206

Add this trial to your favorites

If you are interested in keeping an eye on this trial, you can add it to your list of favorite trials. We'll send you alerts when this trial is updated.

Find a nearby location

You can explore trial locations from around the US and connect directly with a trial coordinator.
Find Nearby Locations

Talk to your doctor

You can print an overview of this trial to take in to your next appointment. Your doctor can help you understand if this trial may be right for you.

Still need help? Send us a message

What's the purpose of this trial?

What will happen during the trial?

You may be able to join this trial if you:

Additional Trial Information

Trial Locations

All Trial Locations

Alabama

University of Alabama at Birmingham O'Neal Comprehensive Cancer Center

Open and Accepting

California

UCSF Helen Diller Comprehensive Cancer Center University of California San Francisco

Open and Accepting

City of Hope Comprehensive Cancer Center Beckman Research Institute

Open and Accepting

Stanford University Cancer Institute (Palo Alto)

Open and Accepting

Colorado

Colorado Blood Cancer Institute Sarah Cannon at Presbyterian/St. Luke's Medical Center (HealthONE)

Open and Accepting

Connecticut

Smilow Cancer Hospital at Yale New Haven

Open and Accepting

Florida

Moffitt Cancer Center Magnolia Campus

Open and Accepting

Massachusetts

Dana-Farber Cancer Institute

Open and Accepting

New York

Memorial Sloan Kettering Cancer Center

Open and Accepting

Mount Sinai Hospital Tisch Cancer Institute

Open and Accepting

Tennessee

Tennessee Oncology - Hayes

Open and Accepting

Washington

Swedish Medical Center (Ballard Campus)

Open and Accepting