A First-in-human, Phase 1, Dose Escalation and Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of GLB-001 in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher-risk Myelodysplastic Syndromes GLB-001
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What's the purpose of this trial?

In this study, researchers want to find the best dose of GLB-001 to treat leukemia. The people in this study have acute myeloid leukemia (AML) or higher-risk myelodysplastic syndrome (HR-MDS) that keeps growing after treatment.

GLB-001 breaks down the CK1-alpha protein, which plays an important role in cancer cell growth and survival. By breaking down this protein, GLB-001 may help slow or stop the growth of AML or HR-MDS. GLB-001 is taken orally (by mouth).

This trial is currently open and accepting patients.

You may be able to join this trial if you:

The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. Further evaluation with a medical professional is required.

To join this study, there are a few conditions. You must:

  • Have AML or HR-MDS that came back or keeps growing even after treatment.
  • Have recovered from the serious side effects of previous therapies before taking GLB-001.
  • Be able to walk and do routine activities for more than half the time you are awake.
  • Be age 18 or older.

Additional Trial Information

Phase 1

Enrollment: 48 patients (estimated)

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Trial Locations

All Trial Locations

View all clinical trial locations sorted by state.

California

City of Hope Comprehensive Cancer Center Beckman Research Institute

Duarte, CA

Open and Accepting

Kansas

University of Kansas Cancer Center

Kansas City, KS

Open and Accepting

New Jersey

Memorial Sloan Kettering Basking Ridge

Basking Ridge, NJ

Open and Accepting

Memorial Sloan Kettering Monmouth

Middletown, NJ

Open and Accepting

Memorial Sloan Kettering Bergen

Montvale, NJ

Open and Accepting

New York

Memorial Sloan Kettering Cancer Center

New York, NY

Open and Accepting

Memorial Sloan Kettering Commack

Commack, NY

Open and Accepting

Memorial Sloan Kettering Nassau

Uniondale, NY

Open and Accepting

Memorial Sloan Kettering Westchester

West Harrison, NY

Open and Accepting

Pennsylvania

Abramson Cancer Center - University of Pennsylvania (UPENN) University of Pennsylvania

Philadelphia, PA

Open and Accepting

Texas

MD Anderson Cancer Center The University of Texas

Houston, TX

Open and Accepting

Washington

Kadlec Clinic Hematology and Oncology

Kennewick, WA

Open and Accepting
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